Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA
نویسندگان
چکیده
منابع مشابه
Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase.
Heavy metal pumps constitute a large subgroup in P-type ion-transporting ATPases. One of the outstanding features is that the nucleotide binding N-domain lacks residues critical for ATP binding in other well-studied P-type ATPases. Instead, they possess an HP-motif and a Gly-rich sequence in the N-domain, and their mutations impair ATP binding. Here, we describe 1.85 A resolution crystal struct...
متن کامل(CuI)P4Se4: An Adduct of Polymeric P4Se4 with CuI
Pure yellow (CuI)P4Se4 was prepared by reaction of stoichiometric amounts of CuI, red P, and gray Se in evacuated silica ampoules. The crystal structure was determined from single crystals at room temperature. (CuI)P4Se4 crystallizes in the orthorhombic system, space group Cmca with a = 14.770 (1) AÊ , b = 12.029 (1) AÊ , c = 12.449 (1) AÊ , V = 2211.9(6) AÊ , and Z = 8. The structure refinemen...
متن کامل717-722 Cui Y.pmd
Diphyllobothrium latum infection in human is not common in China and only 15 cases have been reported since 1927. We document a case of Diphyllobothrium latum infection caused by the ingestion of raw fish in a 23-year-old woman in Dalian (Liaoning Province), and diphyllobothriasis latum in China is briefly reviewed. The patient experienced abdominal discomfort for about 6 months with a history ...
متن کامل579 - 591 Cui J.pmd
Trichinella spiralis surface proteins are directly exposed to the host’s immune system, making them the main target antigens which induce the immune responses and may play an important role in the larval invasion and development process. The analysis and characterization of T. spiralis surface proteins could provide useful information to elucidate the host-parasite interaction, identify the ear...
متن کاملCopA: An Escherichia coli Cu(I)-translocating P-type ATPase.
The copA gene product, a putative copper-translocating P-type ATPase, has been shown to be involved in copper resistance in Escherichia coli. The copA gene was disrupted by insertion of a kanamycin gene through homologous recombination. The mutant strain was more sensitive to copper salts but not to salts of other metals, suggesting a role in copper homeostasis. The copper-sensitive phenotype c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2009
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20091079